Safety assessment
3D safety assessment of drug‑induced organ and vascular effects
Features
- Renal accumulation of antibody drugs
- Cellular dynamics of inflammation and injury
- Whole‑kidney glomeruli counting
- 3D structural analysis
- Deep 3D imaging with CUBIC
Applications
- Renal accumulation of therapeutics
- Drug toxicity‑related cellular changes
- 3D renal structural analysis
Figure. Representative movie for Cisplatin-induced drug toxicity.
特長
- 抗体薬の腎臓内蓄積評価：抗体薬の腎臓への分布および蓄積量を、全臓器スケールで三次元的に可視化・定量
- 炎症・障害に伴う細胞動態解析：薬剤誘発性炎症や組織障害に起因する細胞数の増減を定量評価
- 糸球体数の定量解析：腎臓全体における糸球体数の変化を網羅的にカウントし、薬剤影響を評価
- 腎組織構造変化の解析：糸球体・血管構造の形態変化を三次元的に解析
- CUBIC組織透明化技術：高透明度を実現し、腎臓深部までの高精細3Dイメージングを可能に
応用例
- 抗体医薬品の腎臓内蓄積量評価
- 薬剤誘発性炎症・障害に伴う細胞数変動の定量
- 糸球体数および腎組織構造変化の三次元解析
Figure. Representative movie for Cisplatin-induced drug toxicity.
Features
- 抗体药物肾脏蓄积
- 炎症与损伤细胞动态
- 肾小球计数
- 结构三维分析
- CUBIC 深部成像
Applications
- 抗体药肾脏蓄积
- 毒性细胞变化
- 肾结构分析
Figure. Representative movie for Cisplatin-induced drug toxicity.
Features
- 신장 축적 평가
- 염증·손상 세포 분석
- 사구체 계수
- 구조 분석
- CUBIC 3D 이미징
Applications
- 신장 축적
- 독성 세포 변화
- 신장 구조 분석
Figure. Representative movie for Cisplatin-induced drug toxicity.
Features
- Accumulation rénale
- Dynamique cellulaire
- Comptage glomérulaire
- Analyse structurelle
- Imagerie CUBIC
Applications
- Accumulation rénale
- Changements toxiques
- Analyse rénale
Figure. Representative movie for Cisplatin-induced drug toxicity.
Features
- Renale Akkumulation
- Zelluläre Dynamik
- Glomeruli‑Zählung
- Strukturanalyse
- CUBIC‑Bildgebung
Applications
- Renale Akkumulation
- Toxische Veränderungen
- Nierenanalyse
Figure. Representative movie for Cisplatin-induced drug toxicity.
Features
- Acumulación renal
- Dinámica celular
- Recuento glomerular
- Análisis estructural
- Imagen CUBIC
Applications
- Acumulación renal
- Cambios tóxicos
- Análisis renal
Figure. Representative movie for Cisplatin-induced drug toxicity.
Features
- Накопление в почках
- Клеточная динамика
- Подсчёт клубочков
- Структурный анализ
- CUBIC‑визуализация
Applications
- Накопление в почках
- Токсические изменения
- Анализ почек
Figure. Representative movie for Cisplatin-induced drug toxicity.
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