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2024.04.03論文
Utilizing CUBIC techniques to elucidate neurons in mediating cortical neurovascular coupling
A new study by Ruff et al. sheds light on the fascinating mechanisms by which cortical GABAergic neurons that co-express neuronal nitric oxide synthase and tachykinin receptor 1 (Tacr1) regulate cerebral blood flow through interactions with excitatory pathways.
In the study, the researchers utilized whole brain clearing techniques CUBIC to visualize and analyze the distribution and interactions of Tacr1 neurons across the brain. The AAV-labeled and CUBIC-cleared brain samples were subjected to whole-brain imaging.
By employing tissue clearing techniques and whole-brain imaging, the researchers were able to gain comprehensive insights into the organization and function of Tacr1 neurons within the brain. This approach allowed for detailed visualization of neuronal structures and connectivity patterns on a whole-brain scale, facilitating a deeper understanding of the role of Tacr1 neurons in mediating cortical neurovascular coupling.
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